Extrinsic Pathway of Blood Coagulation and Thrombin in the Cerebrospinal Fluid after Subarachnoid Hemorrhage

Abstract

Thrombin in the blood may not reflect the pathophysiology of SAH. Imbalance between tissue factor and tissue factor pathway inhibitor in the CSF may tend to thrombin generation under normal physiological conditions and also after SAH. Thrombin in the CSF may be involved in the pathophysiology of vasospasm.