Concepedia

High expression of the cysteine proteinase legumain in colorectal cancer – Implications for therapeutic targeting

Mads H. Haugen, Kjetil Boye, Jahn M. Nesland, Solveig Pettersen, Eivind Valen Egeland, Tripti Tamhane, Klaudia Brix, Gunhild M. Mælandsmo, Kjersti Flatmark

European Journal of Cancer · 2014 · 63 citations · 36 references

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References

36

Targeting tumor-associated macrophages as a novel strategy against breast cancer

Yunping Luo · Journal of Clinical Investigation · 2006 · 547 citations · Full text

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Cloning, Isolation, and Characterization of Mammalian Legumain, an Asparaginyl Endopeptidase

Jinq-May Chen, Pam M. Dando, Neil D. Rawlings et al. · Journal of Biological Chemistry · 1997 · 387 citations · Full text

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Brentuximab Vedotin (SGN-35)

Jessica Katz, John E. Janik, Anas Younes · Clinical Cancer Research · 2011 · 363 citations

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Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy.

Chengzao Sun, Haining Huang, Kim D. Janda et al. · PubMed · 2003 · 340 citations

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Lysosomal Trafficking and Cysteine Protease Metabolism Confer Target-specific Cytotoxicity by Peptide-linked Anti-CD30-Auristatin Conjugates

May S.K. Sutherland, Russell J. Sanderson, Kristine A. Gordon et al. · Journal of Biological Chemistry · 2006 · 296 citations · Full text

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