Acrolein and embryogenesis: An experimental study

Comparison of the mutagenicity and teratogenicity of cyclophosphamide and its active metabolites, 4-hydroxycyclophosphamide, phosphoramide mustard, and acrolein.

Barbara F. Hales · PubMed · 1982 · 149 citations

Pharmacy, Pharmacology, Toxicology +13

Teratogenicity of cyclophosphamide metabolites: Phosphoramide mustard, acrolein, and 4-ketocyclophosphamide in rat embryos cultured in vitro

R.E. Mirkes, Alan G. Fantel, Jean C. Greenaway et al. · Toxicology and Applied Pharmacology · 1981 · 82 citations

Pharmacy, Pharmacology, Toxicology +14

Inhibition of nucleic acid and protein synthesis in Escherichia coli by oxidized polyamines and acrolein

Brian W. Kimes, David R. Morris · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · 1971 · 44 citations

Life Sciences, Biochemistry, Molecular Biology +17

Effects of dosage, phenobarbital, and 2-diethylaminoethyl-2,2-diphenylvalerate on the binding of cyclophosphamide and-or its metabolites to the DNA, RNA, and protein of the embryo and liver in pregnant mice.

Vadiraja V. Murthy, Bernard Becker, William J. Steele · PubMed · 1973 · 32 citations

Pharmacy, Pharmacology, Toxicology +16

Investigations on cyclophosphamide treatment during the preimplantation period. II. In vitro studies on the effects of cyclophosphamide and its metabolites 4‐OH‐cyclophosphamide, phosphoramide mustard, and acrolein on blastulation of four‐cell and eight‐cell mouse embryos and on their subsequent development during implantation

Horst Spielmann, Ursula Jacob-Müller · Teratology · 1981 · 28 citations

Veterinary Medicine, Developmental Biology, Pharmacology +17