Investigation of the role of the base in the synthesis of [18F]FLT

Regulation of human thymidine kinase during the cell cycle.

James L. Sherley, Thomas J. Kelly · Journal of Biological Chemistry · 1988 · 447 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Imaging proliferation in brain tumors with 18F-FLT PET: comparison with 18F-FDG.

Wei Chen, Timothy F. Cloughesy, Nirav Kamdar et al. · PubMed · 2005 · 440 citations

Medicine, Nuclear Medicine, Oncology +17

In vivo validation of 3'deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) as a proliferation imaging tracer in humans: correlation of [(18)F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumors.

Hubert Vesselle, John R. Grierson, Mark Muzi et al. · PubMed · 2002 · 299 citations

Medicine, Nuclear Medicine, Oncology +17

3'-Substituted 2',3'-dideoxynucleoside analogs as potential anti-HIV (HTLV-III/LAV) agents

Piet Herdewijn, Jan Balzarini, Erik De Clercq et al. · Journal of Medicinal Chemistry · 1987 · 296 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides

B. Munch-Petersen, L. Cloos, Gerda Tyrsted et al. · Journal of Biological Chemistry · 1991 · 286 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13