FEBS Letters · 2008 · 14 citations · 14 references
Life SciencesCell BiologyOncologyApoptosisCarcinogenesisMolecular OncologyApoptosis In CancerApoptosis RegulationApoptotic Signal TransductionApoptotic SignalingCancer Cell SignalingGrowth Factor SignalingApoptosis Signaling In CancerApoptotic Signaling In CancerCell Growth RegulationP53-mediated ApoptosisPuma FunctionTransforming Growth Factor-beta SignalingTumor Suppressor P53Tumor Suppressor Pathways
Transforming growth factor-beta (TGF-beta) is implicated as a tumor suppressor because it eliminates cancer cells from normal tissues by inhibiting cell growth and inducing apoptosis. Although p53 tumor suppressor is required for TGF-beta-induced p21 WAF1 expression and cell growth inhibition, its role in TGF-beta-induced apoptosis remains unclear. Here, we report that TAp73alpha, which is a member of the p53 family, binds to p53-binding sites in the promoters of proapoptotic Bax and Puma to activate their transcription, and mediates TGF-beta-induced apoptosis in gastric cancer cells. Our findings reveal a novel role of TAp73alpha in the induction of apoptosis by TGF-beta in cancer cells.
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Role for the p53 homologue p73 in E2F-1-induced apoptosis
Meredith S. Irwin, María C. Marín, Andrew C. Phillips et al. · Nature · 2000 · 709 citations
Chemosensitivity linked to p73 function
Meredith S. Irwin, Keiichi Kondo, María C. Marín et al. · Cancer Cell · 2003 · 404 citations · Full text