Binding affinities of rimexolone (ORG 6216), flunisolide and their putative metabolites for the glucocorticoid receptor of human synovial tissue

Correlation between chemical structure, receptor binding, and biological activity of some novel, highly active, 16 alpha, 17 alpha-acetal-substituted glucocorticoids.

Erik Dahlberg, A Thalén, Ralph Brattsand et al. · Molecular Pharmacology · 1984 · 131 citations

Life Sciences, Medicinal Chemistry, Pharmacology +15

Nature of steroid-glucocorticoid receptor interactions: thermodynamic analysis of the binding reaction

Manfred E. Wolff, John D. Baxter, Peter A. Kollman et al. · Biochemistry · 1978 · 105 citations

Life Sciences, Biochemistry, Endocrinology +10

Binding of steroids to the progestin and glucocorticoid receptors analyzed by correspondence analysis

Tiiu Ojasoo, Jean Christophe Dore, Jacques Gilbert et al. · Journal of Medicinal Chemistry · 1988 · 98 citations

Life Sciences, Biochemistry, Endocrinology +17

Flunisolide metabolism and dynamics of a metabolite

M. D. Chaplin, Wendell H. Rooks, Edward W. Swenson et al. · Clinical Pharmacology & Therapeutics · 1980 · 96 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

Glucocorticoid Receptors in Human Synovial Tissue and Relative Receptor Affinities of Glucocorticoid-21-Esters

Martin Pörtner, H Möllmann, Peter Rohdewald · Pharmaceutical Research · 1988 · 27 citations

Medicine, Endocrinology, Pharmacology +6