A Thalén

Influence of 16α,17α-acetal substitution and steroid nucleus fluorination on the topical to systemic activity ratio of glucocorticoids

Ralph Brattsand, A Thalén, K. Roempke et al. · Journal of Steroid Biochemistry · 1982 · 133 citations

Systemic Activity Ratio, Medicine, 16α,17α-Acetal Substitution +6

Correlation between chemical structure, receptor binding, and biological activity of some novel, highly active, 16 alpha, 17 alpha-acetal-substituted glucocorticoids.

Erik Dahlberg, A Thalén, Ralph Brattsand et al. · Molecular Pharmacology · 1984 · 130 citations

Liver metabolism of budesonide in rat, mouse, and man. Comparative aspects.

Staffan Edsbäcker, Paul Andersson, C. Lindberg et al. · Drug Metabolism and Disposition · 1987 · 71 citations

Synthesis and anti-inflammatory properties of budesonide, a new non-halogenated glucocorticoid with high local activity.

A Thalén, Ralph Brattsand · PubMed · 1979 · 67 citations

Inflammation, Medicinal Chemistry, New Non-halogenated Glucocorticoid +14

Development of new glucocorticosteroids with a very high ratio between topical and systemic activities.

Ralph Brattsand, A Thalén, K. Roempke et al. · PubMed · 1982 · 63 citations

Inflammation, Medicinal Chemistry, Anti-inflammatory +14