Influence of 16α,17α-acetal substitution and steroid nucleus fluorination on the topical to systemic activity ratio of glucocorticoids

Ralph Brattsand, A Thalén, K. Roempke, +2

Journal of Steroid Biochemistry

Systemic Activity RatioMedicine16α,17α-Acetal SubstitutionDermatologyGlucocorticoid +4

Correlation between chemical structure, receptor binding, and biological activity of some novel, highly active, 16 alpha, 17 alpha-acetal-substituted glucocorticoids.

Erik Dahlberg, A Thalén, Ralph Brattsand, +4

Molecular Pharmacology

Liver metabolism of budesonide in rat, mouse, and man. Comparative aspects.

Staffan Edsbäcker, Paul Andersson, C. Lindberg, +3

Drug Metabolism and Disposition

Synthesis and anti-inflammatory properties of budesonide, a new non-halogenated glucocorticoid with high local activity.

A Thalén, Ralph Brattsand

PubMed

InflammationMedicinal ChemistryNew Non-halogenated GlucocorticoidPossible EpimersAnti-inflammatory +12

Development of new glucocorticosteroids with a very high ratio between topical and systemic activities.

Ralph Brattsand, A Thalén, K. Roempke, +2

PubMed

InflammationMedicinal ChemistryAnti-inflammatoryHigh RatioAllergy +12

Metabolic pathways of the topical glucocorticoid budesonide in man.

Staffan Edsbäcker, Stefán Hrafn Jónsson, C. Lindberg, +2

Drug Metabolism and Disposition

Metabolic acetal splitting of budesonide. A novel inactivation pathway for topical glucocorticoids.

Staffan Edsbäcker, Paul Andersson, Carl Lindberg, +2

Drug Metabolism and Disposition

High-performance liquid chromatographic determination of epimers, impurities, and content of the glucocorticoid budesonide and preparation of primary standard

Gregory P. Roth, Anders Wikby, Lars Nilsson, +1

Journal of Pharmaceutical Sciences

Food ChemistryBiochemistryGas ChromatographyMedicineMass Spectrometry +9

Development of glucocorticosteroids with enhanced ratio between topical and systemic effects.

A Thalén, Ralph Brattsand, Paul Andersson

PubMed

InflammationMolecular PharmacologyMedicinal ChemistryAnti-inflammatoryMedicine +11

A sensitive radioimmunoassay for budesonide in plasma

G. Wynne Aherne, P Littleton, A Thalén, +1

Journal of Steroid Biochemistry

InflammationSensitive RadioimmunoassayAutoimmune DiseaseImmunologyTherapeutic Efficacy +3