INTERACTION BETWEEN OLEATE AND THE LIPOPROTEINS OF HUMAN SERUM

Abstract

Since the pioneer observations of Hahn (1), who noted that heparin injection caused the disappearance of visible lipemia, and of Anderson and Fawcett (2), who showed that this effect was due not to heparin itself but to a which appeared in plasma after heparin injection, there has been considerable interest in the biochemical and physiological aspects of this phenomenon, often called the reaction. A variety of effects over and above the mere disappearance of turbidity has been attributed to clearing factor action. Evidence presented by several independent groups of investigators (3-7) would appear to establish the fact that in the presence of clearing factor, triglycerides are hydrolyzed in in vitro systems with the liberation of glycerol and free fatty acids. This conclusion is further confirmed by a considerable amount of data from this laboratory which are, as yet, unpublished (8). The lipolytic reaction may be broadly formulated