Globulixanthones A and B, Two New Cytotoxic Xanthones with Isoprenoid Groups from the Root Bark of <i>Symphonia globulifera</i>

Abstract

Bioassay-guided fractionation of a root bark extract of Symphonia globulifera has yielded, in addition to stigmasterol, two new xanthones with isoprenoid units, named globulixanthones A (1) and B (2). The structures of these compounds have been elucidated by spectroscopic means. They possess significant cytotoxicity in vitro against the KB cell line.