Common chromatin structures at breakpoint cluster regions may lead to chromosomal translocations found in chronic and acute leukemias

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

Y Gu, Tatsuya Nakamura, Hansjüerg Alder et al. · Cell · 1992 · 834 citations

Life Sciences, Genetics, Molecular Genetics +13

Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.

Ernest S. Kawasaki, SS Clark, Mazie Coyne et al. · Proceedings of the National Academy of Sciences · 1988 · 722 citations · Full text

Medicine, Molecular Biology, Oncology +17

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

Andrew J. Pierce, Peng Hu, Mingguang Han et al. · Genes & Development · 2001 · 524 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Meiosis-Induced Double-Strand Break Sites Determined by Yeast Chromatin Structure

Tzu-Chen Wu, Michael Lichten · Science · 1994 · 446 citations

Life Sciences, Genetics, Molecular Biology +14

Dietary bioflavonoids induce cleavage in the <i>MLL</i> gene and may contribute to infant leukemia

Reiner Strick, Pamela L. Strissel, Susanne Borgers et al. · Proceedings of the National Academy of Sciences · 2000 · 390 citations · Full text

Medicine, Molecular Biology, Oncology +13