Synergistic interaction of ABCB1 and ABCG2 polymorphisms predicts the prevalence of toxic encephalopathy during anticancer chemotherapy

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity <i>in</i> <i>vivo</i>

Sven Hoffmeyer, Oliver Burk, Oliver von Richter et al. · Proceedings of the National Academy of Sciences · 2000 · 2.4K citations

Medicine, Molecular Genetics, Pharmacology +15

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel, Els Wagenaar, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1995 · 1.1K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group.

Martin Schrappe, Alfred Reiter, Wolfgang Ludwig et al. · PubMed · 2000 · 609 citations

Medicine, Oncology, Pediatrics +17

Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C&gt;T affects mRNA stability

Andrew D. Johnson, Audrey C. Papp, Deanna L. Kroetz et al. · Pharmacogenetics and Genomics · 2005 · 494 citations

Life Sciences, Genetics, Molecular Genetics +14

C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.

Yasuo Imai, Minoru Nakane, Kumie Kage et al. · PubMed · 2002 · 441 citations

Medicine, Oncology, Pharmacology +17