Design, synthesis and evaluation of retinoids with novel bulky hydrophobic partial structures

Identification of a receptor for the morphogen retinoic acid

Vincent Giguère, Estelita S. Ong, Prudimar Segui et al. · Nature · 1987 · 2K citations

Life Sciences, Cell Biology, Molecular Biology +12

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

Richard A. Heyman, David J. Mangelsdorf, Jacqueline A. Dyck et al. · Cell · 1992 · 1.8K citations

Medicine, Medicinal Chemistry, Pharmacology +11

Nuclear receptor that identifies a novel retinoic acid response pathway

David J. Mangelsdorf, Estelita S. Ong, Jacqueline A. Dyck et al. · Nature · 1990 · 1.5K citations

Life Sciences, Cell Biology, Molecular Biology +14

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

Arthur A. Levin, Laurie J. Sturzenbecker, Sonja Kazmer et al. · Nature · 1992 · 1.2K citations

Life Sciences, Genetics, Molecular Biology +14

ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

Paige E. Cramer, John R. Cirrito, Daniel W. Wesson et al. · Science · 2012 · 1K citations

Life Sciences, Neurobiology, Neuroscience +17