Preparative resolution of 2-methyl-4-hexynic acid for the synthesis of optically active m-phenylene PGI2 derivatives and determination of their absolute configuration

Prostaglandin analogs. Part 9. Synthesis of a new chemically and metabolically stable prostacyclin analog with high and long-lasting oral activity

Werner Skuballa, E. Schillinger, C.‐ST. STUERZEBECHER et al. · Journal of Medicinal Chemistry · 1986 · 117 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

Diverse process in [4+2]cycloaddition reaction of silyl enol ethers of N-substituted 2-acetylpyrroles to an indole skeleton

Masatomi Ohno, Sadahiro Shimizu, Shoji Eguchi · Tetrahedron Letters · 1990 · 43 citations

Natural Sciences, Chemistry, Organic Chemistry +9

An Efficient Catalytic Stereoselective Route to a Key Intermediate for the Synthesis of the Long-Lived PGI2 Analog ZK 96480 (CicaprostTM)

E. J. Corey, Christopher J. Helal · Tetrahedron Letters · 1997 · 29 citations

Natural Sciences, Chemistry, Medicinal Chemistry +3

Total Synthesis of Optically Active m-Phenylene PGl2 Derivative: Beraprost

Hiroshi Nagase, Hisanori Wakita, Hideo Yoshiwara et al. · Heterocycles · 2000 · 27 citations · Full text

Pharmacy, Chemistry, Pharmacology +12

Synthesis of 5,6,7-trinor-4,8-inter-m-phenylene PGI2 and Beraprost

Hisanori Wakita, Kazuhisa Matsumoto, Hideo Yoshiwara et al. · Tetrahedron · 1999 · 27 citations

Natural Sciences, Chemistry, Organic Chemistry +1