Hyperparathyroidism Detected by Routine Serum Calcium Analysis

Abstract

Article1 September 1965Hyperparathyroidism Detected by Routine Serum Calcium AnalysisPrevalence in a Clinic PopulationCHARLES E. BOONSTRA, M.D., CHARLES E. JACKSON, M.D., F.A.C.P.CHARLES E. BOONSTRA, M.D.Search for more papers by this author, CHARLES E. JACKSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-3-468 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThough the prevalence of primary hyperparathyroidism is unknown, Keating (1) has reported that its observed frequency in published series reflects primarily the diligence with which it has been sought. In 1962 (2) we reported the results of routine serum calcium analysis on 12,000 consecutive individuals and emphasized that a careful search for hyperparathyroidism must involve the screening of apparently asymptomatic individuals for hypercalcemia. Presented here are the data on 31 cases of hyperparathyroidism and other cases with abnormal serum calcium levels encountered in studying nearly 26,000 consecutive individuals during a 65-month period.METHODSThis investigation was begun in June, 1959,...References1. KEATING FR: Diagnosis of primary hyperparathyroidism: clinical and laboratory aspects. JAMA 178: 547, 1961. CrossrefMedlineGoogle Scholar2. BOONSTRAJACKSON CECE: The clinical value of routine serum calcium analysis. Ann. Intern. Med. 57: 963, 1962. LinkGoogle Scholar3. JACKSON CE: Hereditary hyperparathyroidism associated with recurrent pancreatitis. Ann. Intern. Med. 49: 829, 1958. LinkGoogle Scholar4. KESSLERWOLFMAN GM: An automated procedure for the simultaneous determination of calcium and phosphorus. Clin. Chem. 10: 686, 1964. CrossrefMedlineGoogle Scholar5. FALES FW: Micromethod for determination of serum calcium. J. Biol. Chem. 204: 577, 1953. CrossrefMedlineGoogle Scholar6. BIGGARTWILLIS JHJ: Peptic ulceration and endocrine disease in necropsy material. Lancet 2: 938, 1959. CrossrefMedlineGoogle Scholar7. KARPATIFRAME GB: Neuropsychiatric disorder in primary hyperparathyroidism. Arch. Neurol. (Chicago) 10: 387, 1964. CrossrefMedlineGoogle Scholar8. ST. GOAR WT: Gastrointestinal symptoms as a clue to the diagnosis of primary hyperparathyroidism: a review of 45 cases. Ann. Intern. Med. 46: 102, 1957. LinkGoogle Scholar9. MIEHERTHIBAUDEAUFRAME WCYB: Primary hyperparathyroidism. A diagnostic challenge. Arch. Intern. Med. (Chicago) 107: 361, 1961. CrossrefMedlineGoogle Scholar10. RANDALLKEATING RVFR: Serendipity in the diagnosis of primary hyperparathyroidism. Amer. J. Med. Sci. 236: 575, 1958. MedlineGoogle Scholar11. RIDDICKREISS FAE: Hyperparathyroidism: analysis of recent experiences, clinical spectrum, and diagnostic tests. Ann. Intern. Med. 56: 183, 1962. LinkGoogle Scholar12. MCGEOWNFIELD MGCM: Asymptomatic hyperparathyroidism. Lancet 2: 1268, 1960. CrossrefMedlineGoogle Scholar13. RASMUSSENREIFENSTEIN HEC: in Textbook of Endocrinology, edited by WILLIAMS, R. H., 3rd. W. B. Saunders Company, Philadelphia, 1962, p. 817. Google Scholar14. GORDANEISENBERGLOKENGARDNERHAYAS GSEHFBLT: Clinical endocrinology of parathyroid hormone excess, in Recent Progress in Hormone Research, Vol. 18, edited by PINCUS, G., Academic Press, New York, 1962, p. 297. Google Scholar15. BERSONYALOWAURBACHPOTTS SARSGDJT: Immunoassay of bovine and human parathyroid hormone. Proc. Nat. Acad. Sci. USA 49: 613, 1963. CrossrefMedlineGoogle Scholar16. TASHJIANMUNSON AHPL: Assay of human parathyroid hormone (editorial). Ann. Intern. Med. 60: 523, 1964. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bluffton, IndianaFrom the Departments of Pathology and Internal Medicine, Caylor-Nickel Clinic, Bluffton, Ind.Supported in part by grant A 2901, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Charles E. Boonstra, M.D., Caylor-Nickel Clinic, 303 S. Main Street, Bluffton, Ind. 46714. 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