Two useful methods for the preparation of (R)- and (S)-N-methyl-1-phenyl-2-(1-pyrrolidinyl)ethanamine

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David M. Hodgson, Andrew R. Gibbs, Gary P. Lee · Tetrahedron · 1996 · 337 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9

Preparation of Aminoalkyl Chlorohydrin Hydrochlorides:  Key Building Blocks for Hydroxyethylamine-Based HIV Protease Inhibitors

Pierre L. Beaulieu, Dominik Wernic · The Journal of Organic Chemistry · 1996 · 103 citations

Pharmacy, Chemistry, Medicinal Chemistry +10

Design, Synthesis, and Application of Chiral Nonracemic Lithium Amide Bases in Enantioselective Deprotonation of Epoxides

Debnath Bhuniya, Arpita DattaGupta, Vinod K. Singh · The Journal of Organic Chemistry · 1996 · 85 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Enantioselective conjugate addition to cyclic enones with scalemic lithium organo(amido)cuprates, Part IV. Relationship between ligand structure and enantioselectivity

Bryant E. Rossiter, Masakatsu Eguchi, Guobin Miao et al. · Tetrahedron · 1993 · 82 citations

Natural Sciences, Chemistry, Catalysis +15

2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid .kappa. agonists

Gerard Costello, Roger James, John S. Shaw et al. · Journal of Medicinal Chemistry · 1991 · 75 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16