eNOS Activation Induced by a Polyphenol-Rich Grape Skin Extract in Porcine Coronary Arteries

Abstract

GSE causes endothelium-dependent NO-mediated relaxations of coronary arteries. This effect involves the intracellular formation of ROS in endothelial cells leading to the Src kinase/phosphoinositide 3-kinase/Akt-dependent phosphorylation of eNOS.