Combined Inhibition of PI3K and mTOR Exerts Synergistic Antiproliferative Effect, but Diminishes Differentiative Properties of Rapamycin in Acute Myeloid Leukemia Cells

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Arkaitz Carracedo, Li Ma, Julie Teruya‐Feldstein et al. · Journal of Clinical Investigation · 2008 · 1.4K citations · Full text

Medicine, Oncology, Pharmacology +17

Activation of Akt and eIF4E Survival Pathways by Rapamycin-Mediated Mammalian Target of Rapamycin Inhibition

Shi-Yong Sun, Laura M. Rosenberg, Xuerong Wang et al. · Cancer Research · 2005 · 808 citations

Medicine, Oncology, Pharmacology +13

Survival of acute myeloid leukemia cells requires PI3 kinase activation

Qing Xu, Serge-Emile Simpson, Timothy J. Scialla et al. · Blood · 2003 · 474 citations · Full text

Life Sciences, Cell Biology, Oncology +14

Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model

Carolyn Waugh Kinkade, Mireia Castillo-Martín, Anna M. Puzio‐Kuter et al. · Journal of Clinical Investigation · 2008 · 387 citations · Full text

Medicine, Oncology, Pharmacology +17

Antileukemic activity of rapamycin in acute myeloid leukemia

Christian Récher, Odile Beyne‐Rauzy, Cécile Demur et al. · Blood · 2004 · 296 citations

Medicine, Oncology, Pharmacology +14