Lack of effect of naloxone on pain perception in humans

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

Opiate Receptor: Demonstration in Nervous Tissue

Candace B. Pert, Solomon H. Snyder · Science · 1973 · 2.4K citations

Medicine, Neuroscience, Pharmacology +10

Pain reduction by focal electrical stimulation of the brain: An anatomical and behavioral analysis

David J. Mayer, John C. Liebeskind · Brain Research · 1974 · 717 citations

Life Sciences, Neurology, Neuroscience +16

Analgesia induced in vivo by central administration of enkephalin in rat

James D. Belluzzi, Norman H. Grant, Victor M. Garsky et al. · Nature · 1976 · 528 citations

Medicine, Pharmacology, Neuropharmacology +11

C fragment of lipotropin has a high affinity for brain opiate receptors

A.F. Bradbury, D.G. Smyth, Christopher R. Snell et al. · Nature · 1976 · 486 citations

Life Sciences, Endocrinology, Neuroscience +5