C fragment of lipotropin has a high affinity for brain opiate receptors

Automatic Recording Apparatus for Use in Chromatography of Amino Acids

D. Spackman, William H. Stein, Stanford Moore · Analytical Chemistry · 1958 · 9.6K citations

Natural Sciences, Biochemistry, Chemistry +11

<b>Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide</b>

R. B. Merrifield · Journal of the American Chemical Society · 1963 · 7.6K citations

Natural Sciences, Biochemistry, Chemistry +6

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

Purification and properties

Brian M. Cox, K E Opheim, H. Teschemacher et al. · Life Sciences · 1975 · 1.7K citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

John Hughes · Brain Research · 1975 · 981 citations

Medicine, Neuroscience, Pharmacology +14