Cortisol metabolism by human liver in vitro—I. Metabolite identification and inter-individual variability

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone

F. Peter Guengerich, Ghazi A. Dannan, Stephen Wright et al. · Biochemistry · 1982 · 1K citations

Medicine, Biochemistry, Pharmacology +12

The increase in urinary excretion of 6 beta‐hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction.

Cécile Ged, JM Rouillon, Lydiane Pichard et al. · British Journal of Clinical Pharmacology · 1989 · 332 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily.

Jean Combalbert, Isabelle Fabre, G Fabre et al. · Drug Metabolism and Disposition · 1989 · 306 citations

Medicine, Biochemistry, Pharmacology +16

Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol

Christine M. Hunt, Paul B. Watkins, Paul Saenger et al. · Clinical Pharmacology & Therapeutics · 1992 · 120 citations · Full text

Medicine, Biochemistry, Pharmacology +15

The metabolism of 17 alpha‐ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites.

HS Purba, J.L. Maggs, ML Orme et al. · British Journal of Clinical Pharmacology · 1987 · 106 citations · Full text

Life Sciences, Biochemistry, Drug Metabolism +13