Cephem sulfones as inactivators of human leukocyte elastase. II. Keto-enol tautomerish in cephem-4-ketones.

Quantitative structure-activity relations. 7. The bilinear model, a new model for nonlinear dependence of biological activity on hydrophobic character

Hugo Kubinyi · Journal of Medicinal Chemistry · 1977 · 195 citations

Pharmacy, Biochemistry, Pharmacology +15

Molecular architecture of the cephalosporins. Insights into biological activity based on structural investigations

Robert M. Sweet, Lawrence F. Dahl · Journal of the American Chemical Society · 1970 · 131 citations

Pharmacy, Biochemistry, Medicinal Chemistry +10

Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters

James B. Doherty, Bonnie M. Ashe, Peter L. Barker et al. · Journal of Medicinal Chemistry · 1990 · 73 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +10

Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides

P E Finke, Bonnie M. Ashe, Wilson B. Knight et al. · Journal of Medicinal Chemistry · 1990 · 53 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins

S. K. Shah, Karen A. Brause, Gilbert O. Chandler et al. · Journal of Medicinal Chemistry · 1990 · 48 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7