Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233

SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells

Elaine M. Zeman, Jeremy Brown, Marilyn J. Lemmon et al. · International Journal of Radiation Oncology*Biology*Physics · 1986 · 395 citations

Life Sciences, Cell Biology, Toxicology +8

Hypoxic Sensitizers: Radiobiological Studies at the Cellular Level

Eric J. Hall, Laurie Roizin-Towle · Radiology · 1975 · 203 citations

Medicine, Oncology, Radiation Oncology +17

Potential bioreductive alkylating agents. 1. Benzoquinone derivatives

Lin Ai, Lucille A. Cosby, Charles W. Shansky et al. · Journal of Medicinal Chemistry · 1972 · 199 citations

Pharmacy, Chemistry, Medicinal Chemistry +7

Radiosensitizing and Toxic Effects of the 2-Nitroimidazole Ro-07-0582 in Hypoxic Mammalian Cells

Brian A. Moore, Branko Palcic, L. D. Skarsgard · Radiation Research · 1976 · 169 citations

Medicine, Pharmacology, Radiation Oncology +15

Molecular mechanisms for the hypoxiadependent activation of 3-amino-1,2,4-benzotriazine-1, 4-dioxide (SR 4233)

Keith R. Laderoute, Peter Wardman, Andrew M. Rauth · Biochemical Pharmacology · 1988 · 156 citations

Life Sciences, Biochemistry, Pharmacology +12