Keith R. Laderoute

Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells

Tiffany N. Seagroves, Heather E. Ryan, Han Lu et al. · Molecular and Cellular Biology · 2001 · 627 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element

Nathalie M. Mazure, Eunice Y. Chen, Keith R. Laderoute et al. · Blood · 1997 · 509 citations · Full text

Life Sciences, Biochemistry, Cell Biology +16

5′-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironments

Keith R. Laderoute, Khalid Amin, Joy M. Calaoagan et al. · Molecular and Cellular Biology · 2006 · 437 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L

Ioanna Papandreou, Ai Lin Lim, Keith R. Laderoute et al. · Cell Death and Differentiation · 2008 · 333 citations

Life Sciences, Cancer Biology, Cell Biology +16

Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression.

Nathalie M. Mazure, Eric Chen, P Yeh et al. · PubMed · 1996 · 240 citations

Medicine, Molecular Biology, Oncology +17