SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells

Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells.

Beverly A. Teicher, John S. Lazo, Alan C. Sartorelli · PubMed · 1981 · 559 citations

Medicine, Oncology, Pharmacology +8

The Phenomenon of Reoxygenation and Its Implications for Fractionated Radiotherapy

Robert F. Kallman · Radiology · 1972 · 298 citations

Medicine, Oncology, Radiation Oncology +17

Hypoxic Sensitizers: Radiobiological Studies at the Cellular Level

Eric J. Hall, Laurie Roizin-Towle · Radiology · 1975 · 203 citations

Medicine, Oncology, Radiation Oncology +17

Potential bioreductive alkylating agents. 1. Benzoquinone derivatives

Lin Ai, Lucille A. Cosby, Charles W. Shansky et al. · Journal of Medicinal Chemistry · 1972 · 199 citations

Pharmacy, Chemistry, Medicinal Chemistry +7

Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells.

Jagjit K. Mohindra, Andrew M. Rauth · PubMed · 1976 · 182 citations

Medicine, Pharmacology, Chemotherapy +14