Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome

Down syndrome phenotypes: the consequences of chromosomal imbalance.

Julie R. Korenberg, X N Chen, Roberton D. Schipper et al. · Proceedings of the National Academy of Sciences · 1994 · 788 citations · Full text

Down Syndrome, Chromatin, Developmental Biology +13

Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome

Xavier Altafaj · Human Molecular Genetics · 2001 · 392 citations

Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome.

Muriel T. Davisson, Cecilia Schmidt, Ellen C. Akeson · PubMed · 1990 · 356 citations

Down Syndrome, Chromatin, Chromosome Dynamics +13

<i>Dyrk1A</i> Haploinsufficiency Affects Viability and Causes Developmental Delay and Abnormal Brain Morphology in Mice

Vassiliki Fotaki, Mara Dierssen, Soledad Alcántara et al. · Molecular and Cellular Biology · 2002 · 339 citations · Full text

A Chromosome 21 Critical Region Does Not Cause Specific Down Syndrome Phenotypes

Lisa E. Olson, Joan T. Richtsmeier, Jen M. Leszl et al. · Science · 2004 · 324 citations · Full text

Cytogenetics, Genetics, Molecular Genetics +18