Structure-activity relationship studies of the amide functionality in (p-O-sulfamoyl)-N-alkanoyl tyramines as estrone sulfatase inhibitors

In Situ Estrogen Production via the Estrone Sulfatase Pathway in Breast Tumors: Relative Importance versus the Aromatase Pathway*

Steven J. Santner, Peter D. Feil, Richard J. Santen · The Journal of Clinical Endocrinology & Metabolism · 1984 · 406 citations

Life Sciences, Biochemistry, Oncology +17

Estrone sulfamates: potent inhibitors of estrone sulfatase with therapeutic potential

Nicola M. Howarth, Atul Purohit, Michael Reed et al. · Journal of Medicinal Chemistry · 1994 · 218 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Inactivation of Steroid Sulfatase by an Active Site-Directed Inhibitor, Estrone-3-O-Sulfamate

Atul Purohit, Gary J. Williams, Nicola M. Howarth et al. · Biochemistry · 1995 · 170 citations

Life Sciences, Biochemistry, Pharmacology +13

Sulfamates of various estrogens are prodrugs with increased systemic and reduced hepatic estrogenicity at oral application

W. Elger, Sigfrid Schwarz, Annemarie Hedden et al. · The Journal of Steroid Biochemistry and Molecular Biology · 1995 · 156 citations

Life Sciences, Medicinal Chemistry, Pharmacology +10

Estrone sulfate-sulfatase and 17β-hydroxysteroid dehydrogenase activities: a hypothesis for their role in the evolution of human breast cancer from hormone-dependence to hormone-independence

Jörge R. Pasqualini, Gérard S. Chetrite, B-L. Nguyen et al. · The Journal of Steroid Biochemistry and Molecular Biology · 1995 · 84 citations

Life Sciences, Biochemistry, Oncology +14