Phase I Study of STX 64 (667 Coumate) in Breast Cancer Patients: The First Study of a Steroid Sulfatase Inhibitor

Susannah Stanway, Atul Purohit, L. W. Lawrence Woo, +11

Clinical Cancer Research

Estrone sulfamates: potent inhibitors of estrone sulfatase with therapeutic potential

Nicola M. Howarth, Atul Purohit, Michael Reed, +1

Journal of Medicinal Chemistry

Pharmaceutical ScienceQuantitative PharmacologyAltmetric Attention ScorePharmacotherapyChemical Biology +16

Inactivation of Steroid Sulfatase by an Active Site-Directed Inhibitor, Estrone-3-O-Sulfamate

Atul Purohit, Gary J. Williams, Nicola M. Howarth, +2

Biochemistry

Potent active site-directed inhibition of steroid sulphatase by tricyclic coumarin-based sulphamates

LW Lawrence Woo, Atul Purohit, Bindu Malini, +2

Chemistry & Biology

Steroid SulphataseMedicinal ChemistryBiochemistryTricyclic Coumarin-based SulphamatesMedicine +7

Steroidal and Nonsteroidal Sulfamates as Potent Inhibitors of Steroid Sulfatase

L. W. Lawrence Woo, Nicola M. Howarth, Atul Purohit, +3

Journal of Medicinal Chemistry

2-Substituted Estradiol Bis-sulfamates, Multitargeted Antitumor Agents:  Synthesis, In Vitro SAR, Protein Crystallography, and In Vivo Activity

Mathew P. Leese, Bertrand Leblond, Andrew Smith, +7

Journal of Medicinal Chemistry

Chemoprevention StrategyVitro SarCarbonic Anhydrase IiPharmaceutical ChemistryTumor Biology +18

17β‐hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone‐dependent breast cancer

Joanna M. Day, Paul Foster, Helena J. Tutill, +9

International Journal of Cancer

In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE.

Atul Purohit, L. W. Lawrence Woo, Barry V. L. Potter, +1

PubMed

PathologyGynecologyTricyclic Coumarin SulfamatesPharmacotherapyTumor Biology +18

E-Ring Modified Steroids as Novel Potent Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1

Delphine S. Fischer, G.M. Allan, Christian Bubert, +9

Journal of Medicinal Chemistry

Chiral Aromatase and Dual Aromatase−Steroid Sulfatase Inhibitors from the Letrozole Template: Synthesis, Absolute Configuration, and In Vitro Activity

Paul M. Wood, L. W. Lawrence Woo, Jean‐Robert Labrosse, +8

Journal of Medicinal Chemistry