Design, Synthesis, and Characterization of SO₂-Containing Azabicyclo[3.<i>n</i>.1]alkanes: Promising Building Blocks for Drug Discovery

Abstract

A set of novel SO2-containing azabicyclo[3.n.1]alkanes has been synthesized by the double-Mannich annulation of of the corresponding monocyclic S-ketones. These compounds have been rationally designed as 3D-shaped, conformationally restricted SO2-containing building blocks for drug discovery.