Publication | Closed Access
Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted‐PEG‐Based Micelles for the Treatment of Glioblastoma
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Citations
37
References
2012
Year
NanoparticlesNanotherapeuticsEngineeringBiomedical EngineeringGliomaProtein NanoparticlesNanomedicineTargeted‐peg‐based MicellesTherapeutic NanomaterialsBioimagingRadiation OncologyCoated Ag NpsTumor TargetingPharmacologyBiomolecular EngineeringPharmaceutical NanotechnologyLipophilic Silver NanoparticlesDrug Delivery SystemsTheir Polymeric EntrapmentNano-drug DeliveryLipophilic Ag NpsMedicineU87mg Cell Lines
A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell-specific recognition of the Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50 = 45 μM) has been found on glioblastoma cell lines.
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