Concepedia

Prolonged Convection-enhanced Delivery into the Rat Brainstem

G. Occhiogrosso, Mark Edgar, David I. Sandberg, Mark M. Souweidane

Neurosurgery · 2003 · 65 citations · 32 references

DOI

Abstract

Prolonged convection-enhanced delivery can be applied safely in the rat brainstem with no recognized limitations of V(d) and minimal histological changes beyond the site of infusion. Chronic brainstem infusions may enhance the potential application of convection-enhanced delivery for therapeutic purposes in treating diffuse pontine gliomas.

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