Anionic polymers for decreased toxicity and enhanced in vivo delivery of siRNA complexed with cationic liposomes

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Andrew Fire, Siqun Xu, Mary K. Montgomery et al. · Nature · 1998 · 15.1K citations

Specific Genetic Interference, Natural Sciences, Genetics +9

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

Adam D. Judge, Vandana Sood, Janet R. Shaw et al. · Nature Biotechnology · 2005 · 1.2K citations

Inflammation, Host Response, Allergy +10

PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

Manfred Ogris, Silvia Brunner, Susanne Schüller et al. · Gene Therapy · 1999 · 1.2K citations

Systemic Gene Delivery, Blood Components, Medicine +8

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

Jennifer A. Lockridge, Lucinda Shaw, Karin S. Blanchard et al. · Nature Biotechnology · 2005 · 1.2K citations

Medicinal Chemistry, Viral Hepatitis, Immunology +9

Liposome–polyethylenimine complexes for enhanced DNA and siRNA delivery

Jens Schäfer, Sabrina Höbel, Udo Bakowsky et al. · Biomaterials · 2010 · 192 citations

Nanomedicine, Dna Nanotechnology, Molecular Biology +5