Concepedia

Cellular Uptake Optimization

Cellular Uptake Optimization is a methodological framework in RNA delivery research that systematically enhances the efficiency and specificity of intracellular siRNA internalization through rational design of delivery vehicles, targeting strategies, and cellular interaction mechanisms.

94

Publications

5.6K

Citations

560

Authors

228

Institutions

Publications per year

2017–2026

35

Parents

Publications

94

Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells

Christina Lorenz, Philipp Hadwiger, Matthias John et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 334 citations

, , +17

Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery

Oleh Taratula, Olga B. Garbuzenko, Paul Kirkpatrick et al. · Journal of Controlled Release · 2009 · 319 citations

, , +14

Efficient Intracellular Delivery of Nucleic Acid Pharmaceuticals Using Cell-Penetrating Peptides

Ikuhiko Nakase, Hidetaka Akita, Kentaro Kogure et al. · Accounts of Chemical Research · 2011 · 307 citations

, , +17

An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor

Sumio Chono, Shyh‐Dar Li, Christine C. Conwell et al. · Journal of Controlled Release · 2008 · 237 citations · Full text

, , +14

In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(–PEG)/siRNA complexes

Anastasia Malek, Olivia M. Merkel, Ludger Fink et al. · Toxicology and Applied Pharmacology · 2009 · 183 citations

, , +16

1–5 of 94

Authors

560

  1. LP
    Ling Peng

    Centre National de la Recherche Scientifique, France

    2 publications · 149 citations

    2

    h-index

  2. JD
    Jun Dai

    Huazhong University of Science and Technology, China

    2 publications · 108 citations

    2

    h-index

  3. KR
    Koen Raemdonck

    Ghent University, Belgium

    2 publications · 46 citations

    2

    h-index

  4. XL
    Xiaoding Lou

    Huazhong University of Science and Technology, China

    2 publications · 108 citations

    2

    h-index

  5. XL
    Xiaoxuan Liu

    Centre National de la Recherche Scientifique, France

    2 publications · 149 citations

    2

    h-index

1–5 of 560

Institutions

228

  1. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    25 publications

    1.6K citations

  2. Inserm

    Paris, France

    4 h-index

    12 publications

    810 citations

  3. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    7 publications

    252 citations

  4. Ghent University

    Ghent, Belgium

    3 h-index

    14 publications

    490 citations

  5. Université de Montpellier

    Montpellier, France

    2 h-index

    7 publications

    501 citations

  6. National Tsing Hua University

    Hsinchu, Taiwan

    2 h-index

    7 publications

    441 citations

  7. La Trobe University

    Melbourne, Australia

    2 h-index

    2 publications

    108 citations

  8. Wuhan University

    Wuhan, China

    2 h-index

    4 publications

    246 citations

1–8 of 228

Venues

  1. Journal of Controlled Release

    10 publications · 1.1K citations

    10

    h-index

  2. Biomaterials

    4 publications · 410 citations

    4

    h-index

  3. Chemical Communications

    ChemComm · 3 publications · 90 citations

    3

    h-index

  4. ChemBioChem

    3 publications · 97 citations

    3

    h-index

  5. International Journal of Pharmaceutics

    3 publications · 94 citations

    3

    h-index

1–5