The Development of Hot Melt Extruded Biocompatible Controlled Release Drug Delivery Devices

Abstract

Novel fillers comprising chitosan and k-carrageenan were prepared via hot melt extrusion to examine the effect of percentage filler content on the properties of the scaffold. Cytotoxicity studies showed that hot melt extruded matrices resulted in high levels of compatibility when exposed to the NIH/3T3 cell line. These results indicate that these fillers may be used as a biocompatible, cheap, and viable functional excipients, which can be used to alter the release rate of hot melt extruded dosage forms and may be suitable for temporary biomedical applications such as orthopedic implants and drug delivery systems.