Guanidine‐Containing Molecular Transporters: Sorbitol‐Based Transporters Show High Intracellular Selectivity toward Mitochondria

Abstract

Special delivery: Transporters constructed on a sorbitol scaffold with eight guanidine residues show significant translocation across the cell membrane and the blood–brain barrier and high affinities toward mitochondria in HeLa and KG1a leukemia cells. The picture shows colocalisation of one such transporter (T) with MitoTracker red in KG1a cells (scale bars: 10 μm).