Cellular Uptake of Arginine-Rich Peptides: Roles for Macropinocytosis and Actin Rearrangement

Ikuhiko Nakase, Miki Niwa, Toshihide Takeuchi, +10

Molecular Therapy

Protein SecretionImmunologyCytoskeletonVector PeptidesCellular Physiology +19

Experimental evidence for the functional relevance of anion–π interactions

Ryan E. Dawson, Andreas Hennig, Dominik P. Weimann, +9

Nature Chemistry

Functional RelevanceNatural SciencesChemical BondQuantum ChemistryChemistry +1

High-resolution multi-dimensional NMR spectroscopy of proteins in human cells

Kohsuke Inomata, Ayako Ohno, Hidehito Tochio, +8

Nature

Magnetic Resonance SpectroscopyHuman CellsMolecular BiologyProtein NmrNuclear Magnetic Resonance Spectroscopy +1

Interaction of Arginine-Rich Peptides with Membrane-Associated Proteoglycans Is Crucial for Induction of Actin Organization and Macropinocytosis

Ikuhiko Nakase, Akiko Tadokoro, Noriko Kawabata, +6

Biochemistry

Protein SecretionR8 Peptide UptakeImmunologyGlycobiologyCytoskeleton +17

Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide

Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, +7

Nature Chemistry

Cell-based Drug DeliveryNanomedicineImmunologyAntibody EngineeringMedicine +1

Cellular Internalization and Distribution of Arginine-Rich Peptides as a Function of Extracellular Peptide Concentration, Serum, and Plasma Membrane Associated Proteoglycans

Michie Kosuge, Toshihide Takeuchi, Ikuhiko Nakase, +2

Bioconjugate Chemistry

Protein SecretionImmunocytochemical TechniqueNeuropeptidesImmunologyExtracellular Peptide Concentration +19

Temperature-, concentration- and cholesterol-dependent translocation of <scp>L</scp>- and <scp>D</scp>-octa-arginine across the plasma and nuclear membrane of CD34+ leukaemia cells

Marjan M. Fretz, Neal A. Penning, Saly Al‐Taei, +5

Biochemical Journal

Transient Focal Membrane Deformation Induced by Arginine-rich Peptides Leads to Their Direct Penetration into Cells

H. Hirose, Toshihide Takeuchi, Hiroko Osakada, +6

Molecular Therapy

Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level

Toshihide Takeuchi, Mari Suzuki, Nobuhiro Fujikake, +5

Proceedings of the National Academy of Sciences

Elucidating cell-penetrating peptide mechanisms of action for membrane interaction, cellular uptake, and translocation utilizing the hydrophobic counter-anion pyrenebutyrate

Peter Guterstam, Fatemeh Madani, H. Hirose, +5

Biochimica et Biophysica Acta (BBA) - Biomembranes

Proteinlipid InteractionBiochemistryCell-penetrating Peptide MechanismsPeptide LibraryMembrane Transport +3