Concepedia

A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient

Elena Tamborini, Lorena Bonadiman, Angela Greco, Veronica Albertini, Tiziana Negri, Alessandro Gronchi, Rossella Bertulli, Maurizio Colecchia, Paolo G. Casali, Marco A. Pierotti,

Gastroenterology · 2004 · 325 citations · 15 references

DOI

Concepts

References

15

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

George D. Demetri, Margaret von Mehren, Charles D. Blanke et al. · New England Journal of Medicine · 2002 · 4.4K citations · Full text

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<i>PDGFRA</i> Activating Mutations in Gastrointestinal Stromal Tumors

Michael C. Heinrich, Christopher L. Corless, Anette Duensing et al. · Science · 2003 · 2.3K citations

, , +17

A Tyrosine Kinase Created by Fusion of the <i>PDGFRA</i> and <i>FIP1L1</i> Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome

Jan Cools, Daniel J. DeAngelo, Jason Gotlib et al. · New England Journal of Medicine · 2003 · 1.7K citations · Full text

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KIT activation is a ubiquitous feature of gastrointestinal stromal tumors.

Brian P. Rubin, Samuel Singer, C. Tsao et al. · PubMed · 2001 · 969 citations

, , +17

STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications

David A. Tuveson, Nicholas A. Willis, Tyler Jacks et al. · Oncogene · 2001 · 699 citations

, , +15