Concepedia

Efficient and Regioselective Halogenations of 2-Amino-1,3-thiazoles with Copper Salts

Fabrice G. Siméon, Matthew T. Wendahl, Victor W. Pike

The Journal of Organic Chemistry · 2009 · 20 citations · 16 references

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Concepts

Abstract

Monohalo and dihalo 1,3-thiazole derivatives can be efficiently and selectively prepared under mild conditions from 2-amino-1,3-thiazoles. Halogenations proceed easily in the presence of copper(I) or copper(II) chlorides, bromides, or iodides directly in solution or with supported copper halides.

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