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Involvement of N-6 Adenine-Specific DNA Methyltransferase 1 ( <i>N6AMT1</i> ) in Arsenic Biomethylation and Its Role in Arsenic-Induced Toxicity

Xuefeng Ren, Maria Aleshin, William J. Jo, Russel Dills, David A. Kalman, Chris D. Vulpe, Martyn T. Smith, Luoping Zhang

Environmental Health Perspectives · 2010 · 68 citations · 33 references

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Abstract

Considering that MMAIII is the most toxic arsenical, our data suggest that N6AMT1 has a significant role in determining susceptibility to arsenic toxicity and carcinogenicity because of its specific activity in methylating MMAIII to DMA and other unknown mechanisms.

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