<scp><i>APOE</i></scp>ε2 is associated with milder clinical and pathological <scp>A</scp>lzheimer disease

Abstract

Even when adjusted for age at onset, symptom duration, and other demographic variables, APOEε2 is associated with milder AD pathology and less severe antemortem cognitive impairment compared to APOEε3 and ε4 alleles, suggesting a relative neuroprotective effect of APOEε2 in AD.