Inflammatory prostaglandin E<sub>2</sub> signaling in a mouse model of Alzheimer disease - Concepedia

Concepedia

Publication | Open Access

Inflammatory prostaglandin E<sub>2</sub> signaling in a mouse model of Alzheimer disease

DOI Full Paper Access

90

Citations

43

References

2012

Year

Ju Shi, Qian Wang, Jenny U. Johansson, Xibin Liang, Nathaniel S. Woodling, Prachi Priyam, Taylor Loui, Milton Merchant, Richard Breyer, Thomas J. Montine,

Annals of Neurology

Abstract

Our findings identify the PGE(2) EP3 receptor as a novel proinflammatory, proamyloidogenic, and synaptotoxic signaling pathway, and suggest a role for COX-PGE(2) -EP3 signaling in the development of AD.

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