Inflammatory prostaglandin E<sub>2</sub> signaling in a mouse model of Alzheimer disease

Ju Shi, Qian Wang, Jenny U. Johansson, Xibin Liang, Nathaniel S. Woodling, Prachi Priyam, Taylor Loui, Milton Merchant, Richard Breyer, Thomas J. Montine,

Annals of Neurology · 2012 · 90 citations · 43 references

DOIFull text

Open access

Abstract

Our findings identify the PGE(2) EP3 receptor as a novel proinflammatory, proamyloidogenic, and synaptotoxic signaling pathway, and suggest a role for COX-PGE(2) -EP3 signaling in the development of AD.

References

43