Infection and Immunity · 1985 · 91 citations · 37 references
Life SciencesInfectious DiseasesPathobiologyImmunopathologyInnate ImmunitySepsisBacterial InfectionsBacterial PathogenesisBacterial ToxinsBacterial Virulence FactorsToxin ProductionToxin-mediated PathogenesisBacterial Toxin ProductionPathogenesis Of Bacterial ToxinsPlasmid IntegrationToxic Shock SyndromeToxin FunctionToxin GenesToxin IdentificationVirulence Factor Toxins
Toxic shock syndrome (TSS) toxin 1 (TSST1) is produced by strains of Staphylococcus aureus associated with TSS. Purified TSST1 induces in rabbits a shock-like illness with many features similar to TSS in humans. These symptoms were also induced by TSST1-producing bacteria in diffusion chambers implanted in the rabbit uterus. Naturally occurring TSST1+ strains and a TSST1- strain harboring a pE194-derived plasmid carrying the cloned TSST1 determinant tst gave the same symptoms. TSST1- strains and a TSST1- strain carrying a pE194-tst plasmid with a deletion of the tst gene had no effect in rabbits. The results with the plasmid-carrying TSST1+ and TSST1- strains, which were isogenic apart from tst, show that the toxin is responsible for the illness in rabbits and suggest that it is a major factor in the pathogenesis of TSS.
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The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage
Barry N. Kreiswirth, Sven Löfdahl, M J Betley et al. · Nature · 1983 · 1.3K citations
TOXIC-SHOCK SYNDROME ASSOCIATED WITH PHAGE-GROUP-I STAPHYLOCOCCI
James K. Todd, Mark Fishaut, Frank A. Kapral et al. · The Lancet · 1978 · 1K citations