Concepedia

Interindividual Variability in Acetaminophen Glucuronidation by Human Liver Microsomes: Identification of Relevant Acetaminophen UDP-Glucuronosyltransferase Isoforms

Michael H. Court, Su Duan, Lisa L. von Moltke, David J. Greenblatt, Christopher Patten, John O. Miners, Peter I. Mackenzie

Journal of Pharmacology and Experimental Therapeutics · 2001 · 302 citations · 35 references

DOI

Concepts

References

35

Evaluation of Atypical Cytochrome P450 Kinetics with Two-Substrate Models:  Evidence That Multiple Substrates Can Simultaneously Bind to Cytochrome P450 Active Sites

Ken Korzekwa, N. Krishnamachary, Magang Shou et al. · Biochemistry · 1998 · 519 citations

, , +17

Association of Acetaminophen Hepatotoxicity With Fasting and Ethanol Use

David C. Whitcomb · JAMA · 1994 · 453 citations

, , +12

Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man.

Piter J. Bosma, Jurgen Seppen, Bart Goldhoorn et al. · Journal of Biological Chemistry · 1994 · 449 citations · Full text

, , +11

Molecular basis for deficient acetaminophen glucuronidation in cats

Michael H. Court, David J. Greenblatt · Biochemical Pharmacology · 1997 · 209 citations

, , +5

Cytochrome P-450 2B6 Is Responsible for Interindividual Variability of Propofol Hydroxylation by Human Liver Microsomes

Michael H. Court, Su Duan, Leah M. Hesse et al. · Anesthesiology · 2001 · 209 citations

, , +16