Molecular basis for deficient acetaminophen glucuronidation in cats

Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations

Kiyoshi Yamaoka, Terumichi Nakagawa, Toyozo Uno · Journal of Pharmacokinetics and Biopharmaceutics · 1978 · 2.1K citations

Pharmacy, Clinical Pharmacokinetics, Pharmacokinetics +11

Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man.

Piter J. Bosma, Jurgen Seppen, Bart Goldhoorn et al. · Journal of Biological Chemistry · 1994 · 449 citations · Full text

Life Sciences, Genetics, Molecular Biology +11

Activation of CYP3A4: Evidence for the Simultaneous Binding of Two Substrates in a Cytochrome P450 Active Site

Magang Shou, James Grogan, Julie Mancewicz et al. · Biochemistry · 1994 · 350 citations

Medicine, Biochemistry, Pharmacology +17

Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation

Sahidan Senafi, Douglas J. Clarke, Brian Burchell · Biochemical Journal · 1994 · 242 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Diazepam metabolism by human liver microsomes is mediated by both S‐ mephenytoin hydroxylase and CYP3A isoforms.

Tommy Andersson, John O. Miners, ME Veronese et al. · British Journal of Clinical Pharmacology · 1994 · 222 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17