Journal of Biochemical and Molecular Toxicology · 2013 · 21 citations · 26 references
Life SciencesBiochemistryDrug DiscoveryStructure-activity RelationshipsSynthetic Medicinal ChemistryAmino Acid-derived Natural ProductsAntioxidant DefenseOxidative Damage To BiomoleculesReactive Oxygen SpeciesUltraviolet-visible SpectroscopyAbsorbance SpectroscopyAntioxidant Activity AssaysAntioxidant PropertiesAssayFree Radical ScavengingMolar AbsorptivityScavengingSpectral Absorbance Analysis
ABSTRACT In current study, we report efficient and clean procedure for preparing mycosporine‐like amino acids (MMAs) analogs and evaluate their ultraviolet absorbance properties and antioxidant activities. The ultraviolet radiation absorbance patterns of the compounds were recorded and then used to define their molar absorptivities. The antioxidant activities were assessed using 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging and superoxide radical scavenging assays. Eight of nine compounds showed good activity against superoxide radicals, as only one of the analogs exhibited a measurable IC 50 in the DPPH assay. © 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:305‐312, 2013; View this article online at wileyonlinelibrary.com . DOI 10.1002/jbt.21489
26