Inhibition of EWS-FLI-1 fusion protein with antisense oligodeoxynucleotides

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

Olivier Delattre, Jessica Zucman‐Rossi, Béatrice Plougastel-Douglas et al. · Nature · 1992 · 1.9K citations

Life Sciences, Genetics, Molecular Genetics +17

A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS–family transcription factor, ERG

Poul H. Sorensen, Stephen L. Lessnick, Dolores López‐Terrada et al. · Nature Genetics · 1994 · 745 citations

Medicine, Genetics, Molecular Genetics +12

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

Win May, Mikhail L. Gishizky, Stephen L. Lessnick et al. · Proceedings of the National Academy of Sciences · 1993 · 577 citations

Medicine, Molecular Biology, Oncology +17

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1.

Win May, Stephen L. Lessnick, Benjamin S. Braun et al. · Molecular and Cellular Biology · 1993 · 498 citations · Full text

Medicine, Molecular Biology, Oncology +16

Cytogenetic characterization of selected small round cell tumors of childhood

Jacqueline Whang‐Peng, Timothy J. Triche, Tor Knutsen et al. · Cancer Genetics and Cytogenetics · 1986 · 307 citations

Medicine, Oncology, Pathology +14