Concepedia

Genetic Prodrug Activation Therapy for Breast Cancer: A Phase I Clinical Trial of<i>erb</i>B-2–Directed Suicide Gene Expression

Hardev Pandha, Lesley‐Ann Martin, Anne Rigg, Helen C. Hurst, Gordon Stamp, Karol Sikora, Nicholas R. Lemoine

Journal of Clinical Oncology · 1999 · 145 citations · 29 references

DOI

Abstract

The results of this study, the first targeted gene therapy for breast cancer and the first to use the cytosine deaminase system in human subjects, are encouraging for the development of genetic prodrug activation therapies that exploit the transcriptional profile of cancer cells.

References

29

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