A rapid metal free synthesis of 5-substituted-1H-tetrazoles using cuttlebone as a natural high effective and low cost heterogeneous catalyst

Abstract

A convenient, rapid and metal free synthesis of 5-substituted-1<italic>H</italic>-tetrazoles by [3 + 2] cycloaddition reaction of nitriles with sodium azide. Cuttlebone as a natural low cost heterogeneous catalyst affords 5-substituted-1<italic>H</italic>-tetrazoles rapidly with high efficiency.