Concepedia

Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes <i>In Vivo</i>

Charles W. Kimbrough, Anil Khanal, Matthew Zeiderman, Bigya R. Khanal, Kelly M. McMasters, Selwyn M. Vickers, William E. Grizzle, Lacey R. McNally

Clinical Cancer Research · 2015 · 75 citations · 38 references

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Abstract

Compared with pH-insensitive controls, V7-750 pH-sensitive probe specifically targets pancreatic adenocarcinoma and has minimal off-target accumulation. The noninvasive detection of pH-targeted probes by means of MSOT represents a promising modality to improve the detection and monitoring of pancreatic cancer.

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