Bismuth Sulfide Nanorods as a Precision Nanomedicine for<i>in Vivo</i>Multimodal Imaging-Guided Photothermal Therapy of Tumor

TLDR

The study introduces Bi₂S₃ nanorods as a precision cancer nanomedicine designed for MSOT/CT‑guided photothermal therapy. These nanorods provide multimodal imaging contrast for MSOT and CT while converting absorbed light into heat for targeted tumor ablation. They achieve strong photothermal effect, enhance MSOT/CT imaging, enable effective tumor destruction and metastasis inhibition after intravenous injection, and exhibit low toxicity, validating a triple‑modality therapeutic platform.

Abstract

Here, we present a precision cancer nanomedicine based on Bi2S3 nanorods (NRs) designed specifically for multispectral optoacoustic tomography (MSOT)/X-ray computed tomography (CT)-guided photothermal therapy (PTT). The as-prepared Bi2S3 NRs possess ideal photothermal effect and contrast enhancement in MSOT/CT bimodal imaging. These features make them simultaneously act as "satellite" and "precision targeted weapon" for the visual guide to destruction of tumors in vivo, realizing effective tumor destruction and metastasis inhibition after intravenous injection. In addition, toxicity screening confirms that Bi2S3 NRs have well biocompatibility. This triple-modality-nanoparticle approach enables simultaneously precise cancer therapy and therapeutic monitoring.