Concepedia

Structural insights into µ-opioid receptor activation

Weijiao Huang, Aashish Manglik, AJ Venkatakrishnan, Toon Laeremans, Evan N. Feinberg, Adrian L. Sanborn, Hideaki Kato, Kathryn E. Livingston, Thor S. Thorsen, Ralf C. Kling,

Nature · 2015 · 911 citations · 57 references

Open access

Concepts

MedicineMedicinal ChemistryPharmacologySignal TransductionStructural BiologyStructure-activity RelationshipsDrug-receptor InteractionsLigand BindingOpioid AnalgesicsOpioid PharmacologyReceptor PharmacologyReceptor RegulationDesensitization In Opioid ReceptorsEndogenous Opioid SignalingOpioid Receptor AgonistsOpioid Receptor BindingOpioid Receptor Desensitization

References

57

VMD: Visual molecular dynamics

William Humphrey, Andrew Dalke, Klaus Schulten · Journal of Molecular Graphics · 1996 · 66.6K citations

Natural Sciences, Biophysics, Physics +12

<i>Coot</i>: model-building tools for molecular graphics

Paul Emsley, Kevin Cowtan · Acta Crystallographica Section D Biological Crystallography · 2004 · 31.4K citations · Full text

Life Sciences, Bioinformatics, Biology +17

<i>Phaser</i>crystallographic software

Airlie J. McCoy, Ralf W. Grosse‐Kunstleve, Paul D. Adams et al. · Journal of Applied Crystallography · 2007 · 20.9K citations · Full text

Natural Sciences, Chemistry, Computational Chemistry +16

Wolfgang Kabsch · Acta Crystallographica Section D Biological Crystallography · 2010 · 16.9K citations · Full text

Computing, Computer Science, Computational Geometry +13

<i>MolProbity</i>: all-atom structure validation for macromolecular crystallography

Vincent B. Chen, W.B. Arendall, Jeffrey J. Headd et al. · Acta Crystallographica Section D Biological Crystallography · 2009 · 14.7K citations · Full text

Life Sciences, Bioinformatics, Biophysics +17